gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD38 CAR-T cells bind CD38, become activated via CD3-zeta and 4-1BB costimulation, and kill CD38+ cells through perforin/granzyme-mediated cytolysis (and associated apoptotic pathways).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Surface antigen/ectoenzyme on AML blasts and myeloma plasma cells recognized by CAR
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05442580
disease_id_num_tar_ref
1689
drug_id_num_tar_ref
4571