gene_symbol
HLA-A
hgnc_id
HGNC:4931
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The vaccine primes neoantigen-specific CD8+ T cells that recognize neoantigen peptides presented on HLA-A and kill those tumor cells via perforin/granzyme (and Fas) pathways; HLA-A expression alone is not targeted.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
MHC class I peptide-binding groove; allele-restricted peptide loading
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05749627
disease_id_num_tar_ref
1692
drug_id_num_tar_ref
4583