gene_symbol
HLA-C
hgnc_id
HGNC:4933
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The vaccine primes neoantigen-specific CD8+ T cells that kill cells presenting the neoantigen peptide on HLA class I via perforin/granzyme. HLA-C itself is only the presenter and is not the cytotoxic target.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
MHC class I peptide-binding groove; allele-restricted peptide loading
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05749627
disease_id_num_tar_ref
1692
drug_id_num_tar_ref
4583