gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Tarlatamab binds CD3 on T cells to activate them and bridge to DLL3+ tumor cells; the activated T cells kill DLL3-expressing tumor cells (perforin/granzyme), not the CD3+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
T-cell receptor complex component on T lymphocytes
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06502977
disease_id_num_tar_ref
189
drug_id_num_tar_ref
515