gene_symbol
STEAP1
hgnc_id
HGNC:11378
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
As an ADC, ABBV-969 binds STEAP1 on the cell surface, is internalized, and releases an (undisclosed) cytotoxic payload inside the cell, leading to target cell death.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface antigen; dual-targeting ADC antigen
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06318273
disease_id_num_tar_ref
1704
drug_id_num_tar_ref
4613