gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The vaccine activates dendritic cells and primes EBV-specific T cells. CD4+ T cells recognizing EBV peptides on MHC II (and the CD8+ CTLs they help) kill EBV-positive, MHC II–expressing cells via perforin/granzyme and/or Fas–FasL apoptosis; the drug itself does not directly kill cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Naturally processed EBV epitopes loaded onto autologous APCs; recognized by CD4+ TCRs in an HLA-DR/DP/DQ–restricted manner
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05707910
disease_id_num_tar_ref
1706
drug_id_num_tar_ref
4618