gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
TQB2102 is an anti-HER2 ADC; it binds HER2, is internalized, and releases a topoisomerase I inhibitor that causes DNA damage and cell death. DNA topoisomerase I is the intracellular payload target, not the antigen used to direct killing.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
payload enzyme target; nuclear DNA replication/repair
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05735496
disease_id_num_tar_ref
1712
drug_id_num_tar_ref
4630