gene_symbol
FOLR1
hgnc_id
HGNC:3791
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
An FRα-targeted ADC binds FRα, is internalized, and releases the maytansinoid DM21, which binds tubulin to disrupt microtubules, causing mitotic arrest and apoptosis (with possible bystander effect).
enzyme_product
Off
epitope
Off
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
Biparatopic binding to two independent FRα epitopes; receptor-mediated internalization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05527184
disease_id_num_tar_ref
1717
drug_id_num_tar_ref
4641