gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Obinutuzumab binds CD20 on B cells and kills them via enhanced FcγRIIIa-mediated ADCC by NK cells and ADCP by macrophages, plus induction of direct caspase-independent cell death; limited complement involvement.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Type II CD20 epitope
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05899621
disease_id_num_tar_ref
1724
drug_id_num_tar_ref
4654