gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Obinutuzumab binds CD20 on B cells and engages FcγRIIIa (CD16A) on NK cells/monocytes to trigger ADCC/ADCP, killing CD20+ B cells. CD16A-expressing cells act as effectors, not targets, and are not directly killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc region interaction; afucosylated Fc increases affinity
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05899621
disease_id_num_tar_ref
1724
drug_id_num_tar_ref
4654