gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Elranatamab engages CD3 on T cells to activate them and crosslink to BCMA on tumor cells; activated T cells kill BCMA-positive cells via perforin/granzyme-mediated apoptosis. CD3+ T cells are not directly killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06183489
disease_id_num_tar_ref
1728
drug_id_num_tar_ref
4665