gene_symbol
CD2
hgnc_id
HGNC:1639
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD2 IgG1 binds CD2 on T/NK cells and its Fc engages effector pathways (ADCC via FcγR-bearing cells and complement-dependent cytotoxicity), leading to lysis/depletion of CD2+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Blocks CD2-CD58 costimulatory interaction; depletes CD2+ T and NK cells via ADCC/CDC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06455280
disease_id_num_tar_ref
1730
drug_id_num_tar_ref
4668