gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CRISPR-edited autologous TILs recognize HLA-presented tumor neoantigen peptides via their TCRs and directly lyse target-expressing cells through perforin/granzyme release and death receptor pathways (e.g., Fas–FasL), enhanced by SOCS1/Regnase-1 knockout.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Autologous TCR recognition; targets vary by patient
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06598371
disease_id_num_tar_ref
190
drug_id_num_tar_ref
518