gene_symbol
IL2RA
hgnc_id
HGNC:6008
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti-CD25 IgG binds CD25 on target cells and recruits immune effectors via its Fc domain, triggering ADCC (NK/macrophage-mediated) and complement-dependent cytotoxicity (CDC) to deplete CD25+ cells; IL-2 blockade itself is non-cytotoxic.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Blocks IL-2 binding to the high-affinity IL-2 receptor; may also bind soluble CD25
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT07029958
disease_id_num_tar_ref
1753
drug_id_num_tar_ref
4716