gene_symbol
IL5RA
hgnc_id
HGNC:6017
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Benralizumab binds IL-5Rα on eosinophils/basophils and, via its afucosylated IgG1 Fc, engages FcγRIIIa on NK cells to trigger potent ADCC, inducing apoptosis and depletion of IL-5Rα–expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Afucosylated IgG1 Fc enhances ADCC against IL5RA-expressing cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06288516
disease_id_num_tar_ref
1755
drug_id_num_tar_ref
4720