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gene_symbol
IL2RG
hgnc_id
HGNC:6010
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
This CAR T product targets GPC3; cells are killed when they express GPC3 via T‑cell cytotoxicity (perforin/granzyme, Fas–FasL). IL‑2R common gamma chain (CD132) is only used for IL‑15/IL‑21 signaling in the CAR T cells and is not a cytotoxic target.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Shared co-receptor for IL-15 and IL-21 signaling
trial_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT04715191
disease_id_num_tar_ref
1779
drug_id_num_tar_ref
4785