gene_symbol
IL2RB
hgnc_id
HGNC:6009
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
IL-2/15 receptor beta (CD122) is not the CAR target. These CAR T cells kill GPC3-positive cells via CAR-activated cytolysis (perforin/granzyme); IL-15/IL-21 provide autocrine support and do not mediate killing of IL-2/15Rβ-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Co-receptor for IL-15 signaling
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT04715191
disease_id_num_tar_ref
1779
drug_id_num_tar_ref
4785