gene_symbol
IL15RA
hgnc_id
HGNC:5978
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
These CAR T cells kill GPC3+ tumor cells via T‑cell effector functions (perforin/granzyme). IL‑15Rα is not recognized by the CAR; IL‑15/IL‑21 provide autocrine support to the T cells, not target-cell killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
High-affinity binding subunit for IL-15; supports autocrine/trans-presentation
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT04715191
disease_id_num_tar_ref
1779
drug_id_num_tar_ref
4785