gene_symbol
FKBP1A
hgnc_id
HGNC:3711
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
FKBP12(F36V)-iCasp9 is a safety switch in the engineered CAR T cells; when a dimerizer (e.g., rimiducid) is given, it induces caspase-9 dimerization and apoptosis of the CAR T cells themselves, not target tumor cells.
enzyme_product
Off
epitope
Off
variant
On
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds rimiducid/AP1903 to dimerize and activate iCasp9
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT04715191
disease_id_num_tar_ref
1779
drug_id_num_tar_ref
4785