gene_symbol
CASP9
hgnc_id
HGNC:1511
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Upon administration of a dimerizer drug, iCasp9 in the engineered CAR T cells is activated, triggering the caspase cascade and inducing rapid apoptosis of the iCasp9-expressing cells.
enzyme_product
On
epitope
Off
variant
On
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Apoptosis effector activated upon dimerization by AP1903-bound FKBP12(F36V)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT04715191
disease_id_num_tar_ref
1779
drug_id_num_tar_ref
4785