gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CD16a (Fc gamma RIIIa) on NK cells is an effector receptor bound by the afucosylated Fc of ublituximab to drive ADCC against CD20+ B cells; CD16a-expressing cells are not targeted or killed by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Afucosylated IgG1 Fc increases affinity; mediates ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05877963
disease_id_num_tar_ref
1780
drug_id_num_tar_ref
4789