gene_symbol
MET
hgnc_id
HGNC:7029
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds MET on target cells, is internalized, and releases a topoisomerase I inhibitor payload that blocks DNA replication and causes DNA damage, leading to cell death.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface receptor tyrosine kinase; ADC antigen
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06628310
disease_id_num_tar_ref
1782
drug_id_num_tar_ref
4793