gene_symbol
IGHG1
hgnc_id
HGNC:5525
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
AB-101 NK cells bind the IgG1 Fc of anti-CD20 antibodies via CD16 to engage CD20-opsonized B cells and mediate ADCC; the killed cells are CD20+ B cells, not cells expressing IgG Fc.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CD16 (FcγRIIIa)-mediated ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06265220
disease_id_num_tar_ref
199
drug_id_num_tar_ref
539