gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
An EGFR-targeting ADC binds EGFR on tumor cells, is internalized, and releases a camptothecin-class topoisomerase I inhibitor that causes DNA damage and kills the cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Bispecific ADC co-target with HER3
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06475300
disease_id_num_tar_ref
1797
drug_id_num_tar_ref
4819