gene_symbol
CD7
hgnc_id
HGNC:1695
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR engagement of CD7 activates the engineered T cells to form a cytolytic synapse and kill CD7+ cells via perforin/granzyme–mediated apoptosis (and potentially death-receptor pathways).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface antigen on T cells and NK cells; Ig superfamily glycoprotein
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05716113
disease_id_num_tar_ref
1822
drug_id_num_tar_ref
4873