gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Epcoritamab binds CD3ε on T cells to activate them and simultaneously binds CD20 on B cells, directing perforin/granzyme-mediated killing of CD20+ B cells; CD3ε+ T cells are not the killed targets.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
T-cell receptor/CD3 complex component
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05852717
disease_id_num_tar_ref
1825
drug_id_num_tar_ref
4878