gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Binds CD3ε on T cells to activate and redirect them toward DLL3+ tumor cells; the T cells then kill DLL3-expressing cancer cells via perforin/granzyme release. CD3+ T cells are not the cytotoxic target.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CD3 complex component on T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06077500
disease_id_num_tar_ref
1826
drug_id_num_tar_ref
4883