gene_symbol
CTLA4
hgnc_id
HGNC:2505
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
IgG1 anti-CTLA-4 binds CTLA-4 on Tregs and engages Fc gamma receptors on NK cells/macrophages to mediate ADCC/ADCP (and possibly complement), depleting CTLA-4–expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Minimally blocks CD80/CD86 interaction; engages Fc-gamma receptors for Treg depletion
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06258304
disease_id_num_tar_ref
1828
drug_id_num_tar_ref
4891