gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds CD20 on B cells and recruits FcγRIIIa+ effector cells (e.g., NK cells) to trigger strong ADCC; also induces direct, caspase‑independent cell death (with relatively less complement-mediated lysis).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Type II anti-CD20 epitope; reduced complement activation; induces direct cell death and ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06265220
disease_id_num_tar_ref
199
drug_id_num_tar_ref
541