gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The HER2-targeted ADC binds HER2, is internalized, and releases an intracellular cytotoxic payload that kills the cell; Fc-mediated ADCC may also contribute.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface receptor tyrosine kinase; overexpression-dependent targeting
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05564858
disease_id_num_tar_ref
1830
drug_id_num_tar_ref
4893