gene_symbol
CLDN18
hgnc_id
HGNC:2039
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds CLDN18.2 on tumor cells, is internalized, and releases a topoisomerase I inhibitor payload after linker cleavage, causing DNA damage and apoptotic cell death.
enzyme_product
Off
epitope
On
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
Cell-surface tight junction protein; isoform 2-specific targeting
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06792435
disease_id_num_tar_ref
1838
drug_id_num_tar_ref
4910