gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Cetuximab binds EGFR on target cells and engages Fcγ receptors on NK cells/macrophages to trigger ADCC (and can activate complement), resulting in killing of EGFR+ cells; EGFR blockade is mainly cytostatic.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain (domain III), blocking ligand binding and dimerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05499065
disease_id_num_tar_ref
1844
drug_id_num_tar_ref
4919