gene_symbol
TNFRSF8
hgnc_id
HGNC:11923
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds CD30, is internalized, and releases MMAE via protease cleavage; MMAE disrupts microtubules (tubulin polymerization), causing G2/M arrest and apoptosis of CD30-positive cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC antibody binds CD30; internalization enables protease cleavage of valine–citrulline linker to release MMAE
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05922904
disease_id_num_tar_ref
1850
drug_id_num_tar_ref
4934