gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Brentuximab vedotin binds CD30 on target cells, is internalized, and releases MMAE, which binds beta-tubulin to inhibit microtubule polymerization, leading to G2/M arrest and apoptosis; beta-tubulin expression alone is not selectively targeted.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Released payload MMAE binds β-tubulin to inhibit microtubule polymerization; multiple β-tubulin isoforms may be engaged
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05922904
disease_id_num_tar_ref
1850
drug_id_num_tar_ref
4934