gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Cetuximab binds EGFR on tumor cells and its Fc engages FcγR-bearing effector cells to mediate ADCC (and can activate complement for CDC), causing lysis/apoptosis; EGFR blockade is antiproliferative.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Extracellular domain (ECD)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06227377
disease_id_num_tar_ref
1851
drug_id_num_tar_ref
4939