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gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
IgG1 antibody binds CD38 on target cells; Fc region engages Fcγ receptors on NK cells/macrophages to mediate ADCC/ADCP and activates complement (CDC), leading to depletion of CD38+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Ectoenzyme/receptor; extracellular domain on CD38+ cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06285201
disease_id_num_tar_ref
1860
drug_id_num_tar_ref
4955