gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
MRG003 targets EGFR on tumor cells; after internalization it releases MMAE, which binds the vinca site on beta-tubulin to inhibit microtubule polymerization, causing G2/M arrest and apoptosis. Tubulin expression alone is not directly targeted by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Payload target (MMAE); microtubule polymerization inhibitor
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06530914
disease_id_num_tar_ref
1872
drug_id_num_tar_ref
4979