gene_symbol
TNFRSF17
hgnc_id
HGNC:11913
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
BCMA-targeted CAR T cells bind BCMA on myeloma cells, become activated, and kill target cells via perforin/granzyme-mediated cytotoxicity (and related apoptotic pathways).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Dual-epitope binding CAR targeting membrane BCMA
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05666700
disease_id_num_tar_ref
1873
drug_id_num_tar_ref
4982