gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD3×anti-EGFR bispecific-armed T cells bridge CD3 on T cells to EGFR on tumor cells, forming an immune synapse and inducing T-cell cytotoxicity (perforin/granzyme, Fas/FasL) against EGFR-expressing cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
receptor tyrosine kinase on tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06479239
disease_id_num_tar_ref
1877
drug_id_num_tar_ref
4992