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gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The bispecific antibody binds CD3ε on T cells to activate and redirect them to EGFR-expressing tumor cells; T cells (CD3ε+) are not killed. Cytotoxicity is T-cell mediated (perforin/granzyme) against EGFR-positive targets.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
T-cell receptor complex subunit on T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06479239
disease_id_num_tar_ref
1877
drug_id_num_tar_ref
4992