gene_symbol
TNFRSF13C
hgnc_id
HGNC:17755
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Ianalumab binds BAFF-R on B cells and engages Fcγ receptor–bearing effector cells to mediate ADCC (with possible ADCP/CDC), depleting BAFF-R–expressing cells; BAFF signaling blockade may further promote apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface receptor on B cells; binding blocks BAFF/BLyS signaling and promotes ADCC-mediated B-cell depletion
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06411639
disease_id_num_tar_ref
1880
drug_id_num_tar_ref
5003