gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Cetuximab binds EGFR on target cells and its IgG1 Fc engages Fc gamma receptor–bearing effector cells (e.g., NK cells) to trigger ADCC (and some CDC), causing lysis of EGFR+ cells; EGFR blockade is mainly antiproliferative.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain (domain III), blocks ligand binding and receptor dimerization; IgG1 Fc can mediate ADCC via Fcγ receptors
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06647563
disease_id_num_tar_ref
1884
drug_id_num_tar_ref
5014