gene_symbol
IL3RA
hgnc_id
HGNC:6012
binding_type
receptor ligand recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
IL-3 binds CD123, the fusion is internalized, and the diphtheria toxin domain ADP-ribosylates EF-2, inhibiting protein synthesis and inducing apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds via IL-3 ligand moiety; receptor-mediated internalization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05442216
disease_id_num_tar_ref
1886
drug_id_num_tar_ref
5020