gene_symbol
EEF2
hgnc_id
HGNC:3214
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Tagraxofusp binds CD123 on the cell surface, is internalized, and its diphtheria toxin moiety ADP-ribosylates EF-2 to block protein synthesis and induce apoptosis. EF-2 is not the targeting antigen; its inhibition is a downstream intracellular effect in CD123+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Catalytic ADP-ribosylation of diphthamide residue by diphtheria toxin inhibits protein synthesis
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05442216
disease_id_num_tar_ref
1886
drug_id_num_tar_ref
5020