gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Neoantigen-specific TCRs recognize the mutant peptide–HLA class I complex on tumor cells, activating cytotoxic T cells to kill via perforin/granzyme-mediated apoptosis (± Fas–FasL), with supportive cytokine effects.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
CD8+ TCR recognition; HLA-A/B/C–restricted; patient-specific
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05908643
disease_id_num_tar_ref
1887
drug_id_num_tar_ref
5023