gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
HER2-targeted ADC binds HER2 and is internalized; the deruxtecan payload (topoisomerase I inhibitor) is released intracellularly, causing DNA damage and apoptosis; can also trigger ADCC and a bystander effect.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Trastuzumab component binds extracellular domain (subdomain IV); mediates ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06324357
disease_id_num_tar_ref
1891
drug_id_num_tar_ref
5032