gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC targets HER2, is internalized, and releases deruxtecan that inhibits Topoisomerase I within HER2+ cells, causing DNA damage and apoptosis; ADCC and bystander effects can also contribute.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Deruxtecan (DXd) payload inhibits TOP1 after internalization; bystander effect
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06324357
disease_id_num_tar_ref
1891
drug_id_num_tar_ref
5032