gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
EO-3021 targets CLDN18.2 for uptake; after internalization it releases MMAE, which binds beta-tubulin to inhibit microtubule polymerization, causing G2/M arrest and apoptosis in CLDN18.2-positive cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Vinca-binding site target of MMAE; inhibits microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05980416
disease_id_num_tar_ref
1896
drug_id_num_tar_ref
5046