gene_symbol
CTLA4
hgnc_id
HGNC:2505
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Biparatopic VHHs bind CTLA-4 on target cells, internalize, and release Shiga-like toxin A that depurinates 28S rRNA, blocks protein synthesis, and induces apoptosis of CTLA-4+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Biparatopic VHH binding to two non-overlapping epitopes; internalization-dependent delivery of SLTA payload
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06034860
disease_id_num_tar_ref
1904
drug_id_num_tar_ref
5068