gene_symbol
RNA28S5
hgnc_id
HGNC:37659
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
MT-8421 binds CTLA-4 on target cells, is internalized, and its Shiga-like toxin A payload depurinates 28S rRNA to block protein synthesis and induce apoptosis; cells expressing 28S rRNA alone are not targeted.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Substrate of Shiga-like toxin A (SLTA) N-glycosidase depurination
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06034860
disease_id_num_tar_ref
1904
drug_id_num_tar_ref
5068